Date Published: 29 September 2005

Myelin Suppresses Plasticity in the Mature Brain

Health News from the United States of America (USA)

Health News from the USA

According to this week's edition of the journal 'Science', researchers have found genetic evidence for the hypothesis that myelination, or formation of a protective sheath around a nerve fiber, consolidates neural circuitry by suppressing plasticity in the mature brain.

This has implications for research concerning the restoration of mobility to people who have lost motor functions due to spinal cord injury, multiple sclerosis, Lou Gehrig's disease, and other central nervous system disorders.

" The failure of surviving neurons to reestablish functional connection is most obvious after spinal cord injury, but limited nerve cell regeneration and plasticity is central to a range of neurological disorders, including stroke, head trauma, multiple sclerosis, and neurodegenerative disease," said senior author Stephen Strittmatter, professor in Yale University's Department of Neurology and Neurobiology.

"Recovery of motor function after serious damage to the mature brain is facilitated by structural and synaptic plasticity."

Strittmatter's laboratory studies how myelin in the central nervous system physically limits axonal growth and regeneration after traumatic and ischemic injury, when blood supply is cut off. A physiological role for the myelin inhibitor pathway has not been defined.

Blocking vision in one eye normally alters ocular dominance in the cortex of the brain only during a critical developmental period, or 20 to 32 days postnatal in mice. Strittmatter's lab, working in collaboration with Nigel Daw, M.D., professor of ophthalmology and neuroscience, and his group, found that mutations in the Nogo-66 receptor (NgR) affect plasticity of ocular dominance. In mice with altered NgR, plasticity during the critical period is normal, but it continues abnormally so that ocular dominance later in development is similar to the plasticity of juvenile stages.

Source: Yale University, Connecticut (USA).

Also in the News:

Report that 50% of cancer patients survive at least 10 years - 29 Apr '14

Discovery of the brain circuits involved in emotion - 23 Apr '14

Mathematical beauty activates same brain region as art and music - 13 Feb '14

Effects of Chiari malformation on toy dog breeds - 13 Feb '14

Schizophrenia symptoms linked with disconnect within the brain - 22 Aug '13

Reduction in time taken to diagnose child brain tumour - 12 Jun '13

Fish oil might delay the effects of junk food on the brain - 14 May '13

Gene key to maintaining normal brain function - 5 Jul '12

Although care has been taken when compiling this page, the information contained might not be completely up to date. Accuracy cannot be guaranteed. This material is copyright. See terms of use.

IvyRose Holistic 2003-2020.