Date Published: 1 January 2009

Scientists find new way to 'track' response to cancer drugs

Cancer Research UK

Scientists have found a new way of accurately measuring the success of experimental cancer drugs, according to a study published in Cancer Research* today (Thursday).

The researchers, funded by Cancer Research UK and the Medical Research Council, have developed a new imaging technique that can determine the levels of cancer drugs in normal and cancerous tissue.

A major challenge in drug development is finding the most effective dose – one that is high enough to kill cancer cells without being toxic to healthy cells.

Around 40% of new anti-cancer drugs fail at the early stages because they are eliminated too quickly from the body or do not reach the blood. But scientists have found that the levels of drug in cancer tissue can determine how effective the drug is.

Professor Eric Aboagye, lead author of the study from Imperial College London, said:

"This new technique will be a significant boost to scientists who work in drug discovery. Being able to accurately measure levels of a drug in different tissues, and understanding how this changes with different doses and schedules of the drug is crucial. We hope this will significantly reduce the costs of drug discovery – deciding to stop researching drugs that will be ineffective at an early stage could cut overall costs for drug discovery by up to 7%."

The new technique will use an imaging method called PET, or Positron Emission Tomography. A mildly radioactive tracer is attached to the cancer drug and injected into the patient. A mathematical formula is then used to calculate the levels of the drug in the patient’s blood and tissue.

Dr Lesley Walker, director of cancer information at Cancer Research UK, said:

"Imaging is an invaluable tool in the fight against cancer. Being able to see what’s happening inside patients is vitally important in understanding how treatments are currently working and the best ways to improve them.

Cancer Research UK has identified imaging research as a priority and we have recently invested £50 million over the next five years in partnership with other funding bodies to help us achieve our aim of improving the detection, diagnosis and treatment of cancer."


Source: Cancer Research UK.

Also in the News:

Children in conflict: Darfur, the DRC and Gaza - 30 Dec '08

Northern Ireland Strategic Committee on Food Surveillance Sampling: 2007 Report - 29 Dec '08

Building back better: four years after the Indian Ocean tsunami - 24 Dec '08

Bowel cancer screening set to save thousands of lives - 23 Dec '08

UNICEF airlifts cholera and health supplies to Zimbabwe - 22 Dec '08

Mia Farrow calls for access for aid agencies in Congo - 22 Dec '08

Soccer Aid 2008 raises over £1.14 million for UNICEF - 19 Dec '08

Make Scotland's Roads Safer: reduce drink driving limits - 18 Dec '08

Angels are always there to guide and protect, through long days or short.

Although care has been taken when compiling this page, the information contained might not be completely up to date. Accuracy cannot be guaranteed. This material is copyright. See terms of use.

IvyRose Holistic 2003-2024.