Clinical Neuroscience Neurodegeneration: Exploring Commonalities Across Diseases
Clinical Neuroscience Neurodegeneration: Exploring Commonalities Across Diseases

Sciatica is a common condition arising from compression of, or damage to, a nerve or nerve root.


Sciatica is usually caused by the degeneration of an intervertebral disc, which protrudes laterally to compress a lower lumbar or an upper sacral spinal nerve root. The onset of sciatica can be sudden, e.g. following an awkward lifting or twisting movement.


Sciatica can involve:

  • pain felt down the back and outer side of the thigh, leg, and foot
  • the back being stiff and painful
  • numbness and weakness in the leg


See also diseases and disorders of the nervous system (all on one page).

Further information about the nervous system includes the main parts of the nervous system, parts of the brain and the pathway of a nerve impulse.

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